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Biology subjects

Ekanem, P. E.

Publications and source records attributed to Ekanem, P. E..

2 recordsLinked to original sources

Evaluation Of Bilateral Asymmetry In The Humerus Of Human Skeletal Specimen

Several studies have established a relationship between morphological and behavioural asymmetry making investigations of bilateral bone asymmetry an attractive and important research area. The purpose of this study was to investigate bilateral asymmetry patterns of skeletal specimen from five geographical locations (Rwanda, Burundi, Congo, Kenya and Uganda) at Galloway Osteological Collection, Department of Anatomy, School of Biomedical Sciences, Makerere University College of Health Sciences at Makerere University.\n\nThe angle of torsion and retroversion, mid shaft circumference, length and weight of 232 pairs of humeri were determined. A Torsiometer was used to measure the angle of torsion in degrees according to Krahl and Evans 1945, a tape was used to measure the mid shaft circumference at the level of the apex of the deltoid V and the length in cm was determined. An osteomeric board was used to measure the length of the humerus in centimeters. A weighing balance was used to measure the weight of the humerus in grams.\n\nThe analysis of humeral asymmetry with respect to parameters of the human skeletal specimen at the Galloway Osteological collection Mulago revealed bilateral asymmetrical status observed in the angle of torsion, length, weight and mid-shaft circumference. Our result mostly showed lateralization to the right in all the parameters investigated except the torsion angle which is to the left.\n\nOur investigation revealed that humeral torsion is inversely proportional to weight, length and mid-shaft circumference of the humerus. This study established the existence of bilateral asymmetries in the humeri of all the geographical regions investigated with more asymmetry observed in the male compared with the female.

zoology↗

Behavioural Evaluation of the Anticonvulsant Properties of the Traditional Medicine Anonna Senegalensis on Parabss Drosophila melanogaster Mutants.

Epilepsy is the most common serious neurological disorder affecting 50 million people worldwide, 40 millions of which live in developing countries. Despite the introduction of a dozen of new Anti-Epileptic Drugs (AEDs), one third of the patients continue to have seizure regardless of receiving a AEDs treatment. This emphasize on the need to discover new drugs with different mechanisms of action. Traditional medicine (TM), pays a significant role in the treatment of epilepsy in many countries and offers an affordable and accessible alternative to AEDs. However, the lack of both empirical testing in animal models and clinical data places constrains to their clinical recommendation.\n\nIn this study, we use Drosophila melanogaster as a model for epilepsy and tested the anti-seizure effect of leaf and stem bark aqueous extract form Annona senegalensis, a plant used as anti-convulsant by rural populations in Africa.\n\nOur results show, that at the concentrations tested, the leaf extract of A. senegalensis was more effective than the AEDs phenytoin and phenobarbital to control seizures. These promising results demonstrate that Drosophila is an excellent model for new drug discovery and that it could be used to do large scale screening of TMs for the treatment of epilepsy.

pharmacology and toxicology↗