bioRxiv Science⌕ Search

Biology subjects

Duek, O.

Publications and source records attributed to Duek, O..

2 recordsLinked to original sources

Modeling Decision-Making Under Uncertainty with Qualitative Outcomes

Modeling decision-making under uncertainty typically relies on quantitative outcomes. Many decisions, however, are qualitative in nature, posing problems for traditional models. Here, we aimed to model uncertainty attitudes in decisions with qualitative outcomes. Participants made choices between certain outcomes and the chance for more favorable outcomes in quantitative (monetary) and qualitative (medical) modalities. Using computational modeling, we estimated the values participants assigned to qualitative outcomes and compared uncertainty attitudes across domains. Our model provided a good fit for the data, including quantitative estimates for qualitative outcomes. The model outperformed a utility function in quantitative decisions. Additionally, we found an association between ambiguity attitudes across domains. Results were replicated in an independent sample. We demonstrate the ability to extract quantitative measures from qualitative outcomes, leading to better estimation of subjective values. This allows for the characterization of individual behavior traits under a wide range of conditions. Author SummaryIn the current study, we explored how people make decisions when the outcomes arent easily measured in numbers, such as in medical choices. Traditional mathematical models, which rely on numerical data, often fall short in these situations, leading to a gap in understanding how people evaluate these qualitative outcomes. Using hierarchical Bayesian modeling, we developed a model that bridges this gap by translating qualitative outcomes into individualized quantitative values, enabling us to better understand the underlying decision-making processes. Our model not only provides a better fit to real-world data than existing models with qualitative or quantitative outcomes but also allows for meaningful comparisons of how people handle uncertainty across different decision-making scenarios. This approach opens new doors for studying decision-making in areas where traditional methods struggle, offering a more nuanced view of human behavior in complex situations.

neuroscience↗

Neural patterns differentiate traumatic from sad autobiographical memories in PTSD

For people with post-traumatic stress disorder (PTSD), recalling traumatic memories often displays as intrusions that differ profoundly from processing of regular negative memories. These mnemonic features fueled theories speculating a qualitative divergence in cognitive state linked with traumatic memories. Yet to date, little empirical evidence supports this view. Here, we examined neural activity of PTSD patients who were listening to narratives depicting their own memories. An inter-subject representational similarity analysis of cross-subject semantic content and neural patterns revealed a differentiation in hippocampal representation by narrative type: Semantically similar sad autobiographical memories elicited similar neural representations across participants. By contrast, within the same individuals, semantically thematically similar trauma memories were not represented similarly. Furthermore, we were able to decode memory type from hippocampal multivoxel patterns. Finally, individual symptom severity modulated semantic representation of the traumatic narratives in the posterior cingulate cortex. Taken together, these findings suggest that traumatic memories are a qualitatively divergent cognitive entity.

neuroscience↗