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Biology subjects

Drum, C.

Publications and source records attributed to Drum, C..

2 recordsLinked to original sources

The ecological and economic benefits of sustainable agricultural practices: Evidence from on-farm trials in broad-acre grain crops

O_LISustainable agricultural practices are essential for mitigating the negative environmental impacts of conventional agriculture while ensuring food security. However, widespread adoption of these practices requires robust evidence of their efficacy and economic viability. C_LIO_LIWe co-designed a two-year field trial with farmers and agronomy advisors in Australia, to evaluate the ecological and economic benefits of sustainable agricultural practices for managing the redlegged earth mite, a major pest of Australian grain crops. We compared Novel treatments representing long-term farmer-implemented sustainable agricultural practices based on biological control with Conventional treatments and Plus treatments designed as counterfactuals to disentangle the effects of specific pest control and plant nutrient components. C_LIO_LIRedlegged earth mite densities remained below economic thresholds across all treatments and years, demonstrating effective pest control in both conventional and sustainable systems. Notably, the Novel treatment supported higher densities of beneficial arthropods, indicating increased biological control potential. C_LIO_LIYield and gross profit margins were generally similar between the treatments, indicating that sustainable agriculture practices can maintain profitability while fostering biodiversity. Practical implication. Our study provides evidence that biological control and biofertiliser supplementation can be effectively used to manage agricultural pests and demonstrates the value of close collaboration with farmers and agronomy advisors to conduct ecological field research that has practical applications. C_LI

ecology↗

The novel conserved NAD+ binding micropeptide SGHRT regulates mitochondrial function and metabolism in human cardiomyocytes

AbstractsNicotinamide adenine dinucleotide (NAD) is a critical metabolite and coenzyme for multiple metabolic pathways and cellular processes (1-4). In this study, we identified Singheart, SGHRT as a nuclear genome-encoded NAD+-binding mitochondrial micropeptide. SGHRT, present in both monomeric and dimeric forms, binds directly to NAD, but not NADH or flavin adenine dinucleotide (FAD). Localized to the inner mitochondrial membrane and mitochondrial matrix, SGHRT interacts with the mitochondrial enzymes Succinate-CoA Ligase and Succinate Dehydrogenase. SGHRT deletion in human embryonic stem cell derived cardiomyocytes disrupted mitochondria morphology, decreased total NAD and ATP abundance, and resulted in defective TCA cycle metabolism, the electron transport chain and in Ox-Phos processes. These results comprise the first report of an NAD+-binding micropeptide, SGHRT, required for mitochondrial function and metabolism.

cell biology↗