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Biology subjects

Driscoll, J.

Publications and source records attributed to Driscoll, J..

2 recordsLinked to original sources

Climate benefits of seaweed farming: estimating regional carbon emission and sequestration pathways

Seaweed farming is widely promoted as an approach to mitigating climate change despite limited data on carbon removal pathways and uncertainty around benefits and risks at operational scales. We explored the feasibility of seaweed farms to contribute to atmospheric CO2 reduction in coastal British Columbia, Canada, a region identified as highly suitable for seaweed farming. Using a place-based, quantitative model, we examined five scenarios spanning a range of industry development. Our intermediate growth scenario sequestered or avoided 0.20 Tg CO2e / year, while our most ambitious scenario (with more cultivation and higher production rates) yielded a reduction of 8.2 Tg CO2e /year, equivalent to 0.3% and 13% of annual greenhouse gas emissions in BC, respectively. Across all scenarios, climate benefits depended on seaweed-based products replacing more emissions-intensive products. Marine sequestration was relatively inefficient in comparison, although production rates and avoided emissions are key uncertainties prioritized for future research. Our results show how seaweed farming could contribute to Canadas climate goals, and our model illustrates how farmers, regulators, and researchers could accurately quantify the climate benefits of seaweed farming in local contexts.

ecology↗

Tissue-engineered models of lung cancer premalignancy

Lung cancer is the leading global cause of cancer-related deaths. Although smoking cessation is the best preventive action, nearly 50% of all lung cancer diagnoses occur in people who have already quit smoking. Research into treatment options for these high-risk patients has been constrained to rodent models of chemical carcinogenesis, which are time-consuming, expensive, and require large numbers of animals. Here we show that embedding precision-cut lung slices within an engineered hydrogel and exposing this tissue to a carcinogen from cigarette smoke creates an in vitro model of lung cancer premalignancy. Hydrogel formulations were selected to promote early lung cancer cellular phenotypes and extend PCLS viability up to six weeks. In this study, hydrogel-embedded lung slices were exposed to the cigarette smoke derived carcinogen vinyl carbamate, which induces adenocarcinoma in mice. At six weeks, analysis of proliferation, gene expression, histology, tissue stiffness, and cellular content revealed that vinyl carbamate induced the formation of premalignant lesions with a mixed adenoma/squamous phenotype. Two putative chemoprevention agents were able to freely diffuse through the hydrogel and induce tissue-level changes. The design parameters selected using murine tissue were validated with hydrogel-embedded human PCLS and results showed increased proliferation and premalignant lesion gene expression patterns. This tissue-engineered model of human lung cancer premalignancy is the starting point for more sophisticated ex vivo models and a foundation for the study of carcinogenesis and chemoprevention strategies.

bioengineering↗