Biology subjects

Döring, T.

Publications and source records attributed to Döring, T..

3 recordsLinked to original sources

bioRxiv2025

A Computer Vision Dataset for Pollinator Detection under Real Field Conditions

The widespread decline in biodiversity and abundance of pollinator insects is expected to provoke cascading effects on food security and jeopardize ecosystem services crucial for many crops and wild plants. Pollinator monitoring is a crucial element in preventing further decline of pollinators, to which computer vision approaches can make essential contributions. To facilitate research in such approaches, we present a dataset for pollinator detection with accurate annotations. We develop the dataset with an iterative semi-automatic annotation approach, which leverages YOLO to assist with human annotation. We quantify the impact of multiple levels of errors in annotations on training and report the increase in mAP of 28.7% at the final iteration when compared to the manual annotations. Our dataset encompasses pollinator detection for honeybees and bumblebees across various flower treatments over multiple days. Our dataset facilitates the development of deep learning-based methods for automatic large-scale pollinator detection under various real-world field conditions, as well as adjacent computer vision tasks such as small object detection and label correction.

ecology↗

bioRxiv2025

A rapid transfer of virions coated with heparan sulfate from the ECM to cell surface CD151 defines a step in the human papillomavirus infection cascade

Human Papillomaviruses (HPVs) are the underlying cause of several types of cancer, albeit they are mostly known for their association with cervical carcinoma. The virions reach their target cells through a break in the epithelial barrier. After binding to heparan sulfate (HS) of the extracellular matrix (ECM), they are recruited via actin-dependent mechanisms to the cell surface where they co-internalize with the entry factor CD151. The in vivo occurring active recruitment from the ECM to the cell surface may be bypassed in cell culture where virions reach the cell surface simply by passive diffusion. To specifically investigate these early events of the infection cascade, we use HaCaT keratinocytes as they produce a robust ECM enabling for abundant virion binding to ECM components such as HS before transfer to cell surface receptors and infection. Employing microscopy, we focus on the basal membrane that for virions is difficult to access by diffusion. We block the active recruitment from ECM attachment sites to the cell body, release the blocking, and monitor the association of virions with CD151 or HS. We observe quick virion recruitment from the ECM to the cell body within 15 min. During recruitment, virions associate with the tetraspanin CD151 present at the cell border or at filopodia. These virions are decorated with HS, which they lose in the next few hours, presumably prior to endocytosis. Our observations reveal a rapid step in the HPV infection cascade: the transfer of HS-coated virions from the ECM to CD151. This step is too fast to account for the asynchronous uptake of HPVs which is likely driven by glycan- and capsid processing.

microbiology↗

bioRxiv2021

The impact of age and education on phonemic and semantic verbal fluency: Behavioral and fMRI correlates

The purpose of this study was to examine the impact of age and education on the neural and behavioral correlates of verbal fluency. Forty-eight healthy adult participants were included: high-educated young and elderly, low-educated young and elderly. Participants performed semantic and phonemic and a control task during fMRI scanning. The phonemic fluency data showed an education effect across age groups. As for the semantic fluency data, there was an education effect only in young participants. The second-level fMRI results showed, in phonemic fluency, a main effect of age in the left posterior cingulate, superior temporal gyrus (STG) and right caudate, whereas the main effect of education involved activation in the right semantic fluency, there were a main effect of age in the left paracentral lobule and posterior cingulate, a main effect of education in the left claustrum and an interaction in the right claustrum and STG and the hippocampus bilaterally.

neuroscience↗