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Dargie, A.

Publications and source records attributed to Dargie, A..

2 recordsLinked to original sources
bioRxiv2019

Prevalence of Alcohol use during pregnancy and its association with partner alcohol use in East Africa: systematic review and meta-analysis

Introductionmaternal alcohol beverages consumption (any amount) during pregnancy can result in multiple major health and social problems both for the mother and fetus; including miscarriage, stillbirth, low birth weight, and prematurity. At the regional and national level, alcohol use prevalence data is a use full indicator for maternal and child health.\n\nMethodsthe researchers were searched for studies using a computerized search engine, main electronic databases, and other applicable sources. Observational studies (case-control, crosssectional and cohort) which assess the prevalence of alcohol use and associated factors among pregnant mothers in East Africa were eligible. Data was extracted thoroughly by two authors independently and screened for eligibility. The Pooled prevalence of alcohol use during pregnancy and its association with partner alcohol use was determined by using Epi data version 14 statistical software.\n\nResultsthe study included eighteen studies with the total sample size of 41,022 and The overall pooled prevalence of alcohol use during pregnancy from the random effects method was found to be 18.85% (95% CI; 11.26, 26.44). The overall weighted odds ration revealed that pregnant women partners alcohol use did not have a significant association with study subjects alcohol use during pregnancy; i.e. OR=0.32 (95% CI: -0.39, 1.03).\n\nConclusionsThe overall alcohol use (any amount) during pregnancy is higher in magnitude and pregnant mothers who had alcohol user partner had no association with their use of alcohol beverages. The prevalence of alcohol use during pregnancy may be underestimated in the current study due to social desirability bias. Since related study articles were found only in four East African countries, the region may be under-represented due to the limited number of studies included.

pharmacology and toxicology↗
bioRxiv2019

The magnitude of neonatal mortality and its predictors in Ethiopia: a systematic review and meta-analysis.

AbstractsO_ST_ABSBackgroundC_ST_ABSAlthough neonatal death is a global burden, it is the highest in Sub Saharan Africa countries such as Ethiopia. This study was aimed to provide pooled national prevalence and predictors of neonatal mortality in Ethiopia.\n\nObjectiveTo assess the pooled prevalence and predictors of neonatal mortality in Ethiopia.\n\nSearch Strategyglobal databases were systematically explored. Systematically searched using the following databases: Boolean operator, Cochrane library, PubMed, EMBASE, HINARI, and Google Scholar. Selection, screening, reviewing and data extraction was done by two reviewers independently using Microsoft excel spread sheet. The modified Newcastle-Ottawa Scale (NOS) and the Joanna Briggs Institute Prevalence Critical Appraisal tools were used to assess the quality of evidence\n\nSelection criteriaAll studies conducted in Ethiopia and reporting the prevalence and predictors of neonatal mortality were included\n\nData Collection and AnalysisData were extracted using a Microsoft Excel spreadsheet software and imported into STATA Version 14 s for further analysis. The pooled effect size with 95% confidence interval of neonatal mortality rate was determined using a weighted inverse variance random-effects model. Publication bias was checked using funnel plots, Eggers and baggers regression test. Heterogeneity also checked by Higginss method. A random effects meta-analysis model was computed to estimate the pooled effect size (i.e. prevalence and odds ratio). Moreover, subgroup analysis based on region, sample size and study design were done.\n\nResultsAfter reviewing 88 studies, 12 studies fulfilled the inclusion criteria and were included in the meta-analysis. The pooled national prevalence of neonatal mortality in Ethiopia was 16.3% (95% CI: 11.9, 20.7, I2 =88.6%). The subgroup analysis indicated that the highest prevalence was observed in Amhara region with a prevalence of 20.3% (95% CI: 9.6, 31.1, I2 =98.8) followed by Oromia, 18.8% (95%CI: 11.9,49.4, I2=99.5). Gestational age AOR,1.14 (95% CI: 0.94, 1.3), neonatal sepsis (OR:1.2(95% CI: 0.8, 1.5), respiratory distros (OR: 1.2(95% CI: 0.8, 1.5) and place of residency (OR:1.93 (95% CI:1.1,2.7) were the most important predictor.\n\nConclusionsneonatal mortality in Ethiopia was significantly decreased than the national report. There was evidence that neonatal sepsis, gestational age, respiratory distress were the significant predictors. We strongly recommended that health care workers should give a priority for the identified predictors.

developmental biology↗