bioRxiv ScienceSearch

Biology subjects

Cordi, M.

Publications and source records attributed to Cordi, M..

2 recordsLinked to original sources

Improving night-time sleep with hypnotic suggestions

Slow-wave sleep (SWS) is fundamental for maintaining our health and well-being, and SWS is typically reduced in stress-related sleep disturbances and age-related sleep disorders. We have previously reported that exposure to hypnotic suggestions before sleep effectively increases the duration of SWS during a midday nap in younger and older women suggestible for hypnosis.\n\nHowever, it remains unclear whether this beneficial effect of hypnosis on SWS can be generalized to night-time sleep and men. Therefore, we tested the effect of the hypnotic suggestions on SWS across an 8 hours night-time sleeping interval in 43 healthy young French-speaking subjects (19 males) of high and low suggestibility. In accordance with our previous results, listening to hypnotic suggestions before sleep increased the amount of SWS in highly suggestible subjects significantly by 13 min compared to a control condition in both genders. Particularly in the first hour, slow-wave activity was significantly increased after hypnosis as compared to the control night in high suggestible. The hypnosis-induced benefits on objective sleep parameters were also reflected in increased subjective sleep quality ratings. Our results demonstrate that hypnotic suggestions are an effective tool to deepen sleep and improve sleep quality also across a whole night of sleep in young healthy men and women. Our findings provide an important basis for the examination and potential application of hypnosis to improve deep sleep in populations with sleep disturbances.

neuroscience

Reactivating vocabularies in the elderly

Quality of memory and sleep decline with age, but the mechanistic interactions underlying the memory function of sleep in older adults are still unknown. It is widely assumed that the beneficial effect of sleep on memory relies on reactivation during Non-rapid eye movement (NREM) sleep, and targeting these reactivations by cue re-exposure reliably improves memory in younger participants. Here we tested whether the reactivation mechanism during sleep is still functional in old age by applying targeted memory reactivation (TMR) during NREM sleep in healthy adults over 60 years. In contrast to previous studies in young participants, older adults memories do not generally benefit from TMR during NREM sleep. On an individual level, a subgroup of older adults still profited from cueing during sleep. These improvers tended to have a better sleep efficiency than non-improvers. In addition, the oscillatory results resembled those obtained in younger participants, involving increases in theta (~6Hz) and spindle (~13 Hz) power for remembered and gained words in a later time windows. In contrast, non-improvers showed no increases in theta activity and even strongly reduced spindle power for later gained vs. lost words. Our results suggest that reactivations during sleep might lose their functionality for memory in some older adults, while this mechanism is still intact in a subgroup of participants. Further studies need to examine more closely the determinants of preserving the memory function of sleep during healthy aging.\n\nGrant informationThe study was supported by grant of the Swiss National Science Foundation (SNSF) No. 100014_162388. T.S. is supported by a grant of the Swiss National Science Foundation (SNSF) No. P2ZHP1_164994.\n\nAbbreviations

neuroscience