bioRxiv Science⌕ Search

Biology subjects

Chishty, H. A.

Publications and source records attributed to Chishty, H. A..

2 recordsLinked to original sources

Using Dynamic Bayesian Optimization to Induce Desired Effects in the Presence of Motor Learning: a Simulation Study

Human-in-the-loop (HIL) optimization is a control paradigm used for tuning the control parameters of human-interacting devices while accounting for variability among individuals. A limitation of state-of-the-art HIL optimization algorithms such as Bayesian Optimization (BO) is that they assume that the relationship between control parameters and user response does not change over time. BO can be modified to account for the dynamics of the user response by implementing time into the kernel function, a method known as Dynamic Bayesian Optimization (DBO). However, it is unknown if DBO outperforms BO when the human response is characterized by models of human motor learning. In this work, we simulated runs of HIL optimization using BO and DBO towards establishing if DBO is a suitable paradigm for HIL optimization in the presence of motor learning. Simulations were conducted assuming either purely time-dependent participant responses, or assuming that responses would arise from state-space models of motor learning capable of describing both adaptation and use-dependent learning behavior. Statistical comparisons indicated that DBO was never inferior to BO, and, after a certain number of iterations, generally outperformed BO in convergence to optimal inputs and outputs. The number of iterations beyond which DBO was superior to BO occurred earlier when the input-output relationship of the simulated responses was more dynamic. Our results suggest that DBO may improve the performance of HIL optimization over BO when a sufficient number of iterations can be evaluated to accurately distinguish between unstructured variability (noise) and learning.

bioengineering↗

A Multi-objective Simulation-Optimization Framework for the Design of a Compliant Gravity Balancing Orthosis

Flexion-synergy is a stereotypical movement pattern that inhibits independent joint control for those who have been affected by stroke; this abnormal co-activation of elbow flexors with shoulder abductors significantly reduces range of motion when reaching against gravity. While wearable orthoses based around compliant mechanisms have been shown to accurately compensate for the arm at the shoulder, it is unclear if accurate compensation can also be achieved while minimizing device bulk. In this work, we present a novel, multi-objective simulation-optimization framework towards the goal of designing practical gravity-balancing orthoses for the upper-limb. Our framework includes a custom built VB.NET application to run nonlinear finite element simulations in SolidWorks, and interfaces with a MATLAB-based particle swarm optimizer modified for multiple objectives. The framework is able to identify a set of Pareto-optimal compliant mechanism designs, confirming that compensation accuracy and protrusion minimization are indeed conflicting design objectives. The preliminary execution of the simulation-optimization framework demonstrates a capability of achieving designs that compensate for almost 90% of the arms gravity or that exhibit an average protrusion of less than 5% of the arm length, with different trade-offs between these two objectives.

bioengineering↗