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Catacchio, C. R.

Publications and source records attributed to Catacchio, C. R..

4 recordsLinked to original sources

Genomic characterization and evolutionary path of human satellite 1B in primates highlight a dynamic relationship with transposable elements

Human Satellite 1B (HSat1B) remains one of the least characterized classical human satellite DNAs, despite its massive abundance on the human Y chromosome. Its tripartite ~2.5 kb monomer - comprising an AluY fragment, a GC-rich unit (here named H1B) and an AT-rich block - points to an evolutionary origin tightly linked to transposable elements (TEs). Here, we present the first comprehensive comparative genomic, phylogenetic and transcriptional characterization of HSat1B across 10 primate species using Telomere-to-Telomere (T2T) and chromosome-scale long-read assemblies, combined with DNA-FISH, RNA-FISH and long-read transcriptomic analyses. We demonstrate that while canonical tandem HSat1B arrays are restricted to Homininae (human, chimpanzee, bonobo and gorilla), the core H1B unit and its structural variants (H1Bsv1 and H1Bsv2) occur across all 10 primate genomes, including strepsirrhines (lemur). This indicates that the H1B sequence predates the assembly of the composite HSat1B monomer by at least 60 million years. H1B variants consistently map within TE-rich genomic contexts, supporting a stepwise, TE-mediated model of satellite diversification and mobilization. Within Homininae, humans exhibit a dramatic lineage-specific expansion driven by Yq12 amplification (~14.2 Mb; 92% of total genomic content), whereas non-human great apes carry smaller, highly polymorphic autosomal and Y-linked arrays. Finally, we show that H1B-containing sequences are transcriptionally active in human and gorilla nuclei via RNA-FISH and characterize heterogeneous H1B/Alu chimeric non-coding transcripts in the human male germline. Collectively, our findings uncover the birth and Homininae-specific expansion of a composite satellite DNA seeded by an ancient primate sequence module and sculpted by transposable elements.

genomics↗

A segmental duplication-mediated deletion leads to neocentromere formation in orangutans

Centromeres ensure faithful chromosome segregation, yet how new centromeres arise and replace canonical ones remains poorly understood. Here, we investigate a polymorphic centromere repositioning event on the orangutan chromosome 10 using near-telomere-to-telomere assemblies, epigenetic profiling, and population-scale data. We identify striking heterogeneity in canonical centromeres, ranging from large, higher-order repeat -satellite arrays to short, monomeric -satellite tracts, alongside the emergence of neocentromeres lacking -satellite DNA. We show a segmental duplication-mediated deletion of 3.6 Mbp that removed the higher-order repeat array, promoting centromere repositioning and neocentromere formation. Phylogenetic analyses reveal complex evolutionary dynamics, including introgression and incomplete lineage sorting in orangutan lineages. These findings demonstrate that centromere identity can evolve through structural variation and epigenetic reprogramming, highlighting its remarkable plasticity in primate genomes.

genomics↗

CENdetectHOR: a comprehensive tool for CENtromere profiling and HOR detection

Centromeres are essential for accurate chromosome segregation and are characterized by long arrays of repetitive satellite DNA, showing extensive variation in sequence, length, and organization across species. Despite extensive research, fully characterizing centromeric DNA has been challenging due to its repetitive nature and rapid evolution. Here, we present CENdetectHOR, a computational tool to identify and analyze higher-order repeat (HOR) arrays in centromeric regions across diverse organisms, requiring no a priori information. We validate its efficacy using human and arabidopsis genomes, demonstrating its ability to reveal the complexity and diversity of centromeric architectures. CENdetectHOR also recognizes HOR variants, elucidating interindividual and interspecific variations in centromeric regions. These findings establish CENdetectHOR as a powerful, versatile, and rapid tool for advancing research on centromere structure, evolution, and function.

genetics↗

Centromere formation remodels chromatin fibre structure

Human centromeres appear as constrictions on mitotic chromosomes and form a platform for kinetochore assembly in mitosis. Biophysical experiments led to a suggestion that repetitive DNA at centromeric regions form a compact scaffold necessary for function, but this was revised when neocentromeres were discovered on non-repetitive DNA. To test whether centromeres have a special chromatin structure we have analysed the architecture of a neocentromere. Centromere formation is accompanied by RNA pol II recruitment and active transcription to form a decompacted, negatively supercoiled domain enriched in open chromatin fibres. In contrast, centromerisation causes a spreading of repressive epigenetic marks to surrounding regions, delimited by H3K27me3 polycomb boundaries and divergent genes. This flanking domain is transcriptionally silent and partially remodelled to form compact chromatin, similar to satellite-containing DNA sequences, and exhibits genomic instability. We suggest transcription disrupts chromatin to provide a foundation for kine-tochore formation whilst compact pericentromeric heterochromatin generates mechanical rigidity.

molecular biology↗