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Carrion, C.

Publications and source records attributed to Carrion, C..

2 recordsLinked to original sources

Assessing the social impact of an online course on the clinical management of Cutaneous Leishmaniasis: A qualitative study

BackgroundIn conjunction with the World Health Organization (WHO), Universitat Oberta de Catalunya (UOC) has implemented training in the treatment of cutaneous leishmaniasis (CL) for health professionals in countries where the condition is highly endemic through an interactive on-line course. With three editions of the course successfully completed, we consider assessment of the courses social impact through analysis of the outcomes beyond knowledge acquisition to be of paramount importance.\n\nMethodology/Principal findingsTo this end, we have conducted a study using the Theory of Change theoretical approach, combined with an exploration of students experiences through in-depth interviews before, during and after taking the course. These testimonies have been analyzed and classified according to their type of result - outputs, outcomes and longer-term impacts - and distributed along three different levels: individual, collective (meso), and systemic change. Insights about intercultural communication in qualitative research are discussed in relation to the characteristics of UOC researchers and the class composition of faculty and students in the Middle East and North Africa countries (MENA) region.\n\nConclusions/SignificanceThis analysis fills a gap in the knowledge of social impact assessment through the establishment of a new methodological approach. The course has proven to be a valuable source of social capital and provided a space to build a network of professionals with a shared focus on how to treat CL in particular - a community of practice - and increase knowledge of other skin NTDs.\n\nAuthor summaryNeglected tropical diseases (NTDs) affecting the skin (Buruli ulcer, cutaneous leishmaniasis, post-kala-azar dermal leishmaniasis, leprosy, lymphatic filariasis, mycetoma, onchocerciasis, scabies and yaws) cause considerable disability, increase stigma and exacerbate poverty. Cutaneous leishmaniasis (CL) is one of the most neglected NTDs. It has an estimated incidence of between 900,000 and 1.3 million new cases worldwide each year. A co-venture between the World Health Organization (WHO) and Universitat Oberta de Catalunya (UOC) has developed an on-line interactive course entitled \"Clinical management of CL\" to provide health personnel with thorough and up-to-date information on the various aspects of CL. Using a new methodological approach, we have conducted a social impact assessment of this training program in order to identify the different type and level of results. The most significant impact has been the mobilizing of students and professors from the different editions of the course in a community of practice, thereby enhancing learning, knowledge sharing and effectivity.

scientific communication and education

Glomerulosclerosis and kidney failure in a mouse model of monoclonal immunoglobulin light-chain deposition disease

Light chain deposition disease (LCDD) is a rare disorder characterized by glomerular and peritubular amorphous deposits of a monoclonal immunoglobulin (Ig) light chain (LC), leading to nodular glomerulosclerosis and nephrotic syndrome. We developed a transgenic model using site-directed insertion of the variable domain of a pathogenic human LC gene into the mouse Ig kappa locus, ensuring its production by all plasma cells. High free LC levels were achieved after backcrossing with mice presenting increased plasma cell differentiation and no Ig heavy chain (HC) production. Our mouse model recapitulates the characteristic features of LCDD, including progressive glomerulosclerosis, nephrotic-range proteinuria and finally, kidney failure. The variable domain of the LC bears alone the structural properties involved in its pathogenicity. RNA sequencing conducted on plasma cells demonstrated that LCDD LC induces endoplasmic reticulum stress, likely accounting for the high efficiency of proteasome inhibitor-based therapy. Accordingly, reduction of circulating pathogenic LC was efficiently achieved and not only preserved renal function, but partially reversed kidney lesions. Finally, transcriptome analysis of pre-sclerotic glomeruli revealed that proliferation and extracellular matrix remodelling represented the first steps of glomerulosclerosis, paving the way for future therapeutic strategies in LCDD and other kidney diseases featuring diffuse glomerulosclerosis, particularly diabetic nephropathy.

pathology