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Cardenas, L.

Publications and source records attributed to Cardenas, L..

4 recordsLinked to original sources

The nitrification inhibitor DMPP preferentially suppresses ammonia-oxidising bacteria and reduces nitric oxide emissions in an archaeal-dominated grassland soil.

Aims Although ammonia-oxidising archaea (AOA) dominate nitrifier communities in many agricultural soils, the contribution of the less abundant ammonia-oxidising bacteria (AOB) to nitrogen oxide emissions, particularly nitric oxide, remains poorly understood. This study investigated the roles of AOA and AOB in regulating nitric oxide (NO) and nitrous oxide (N2O) emissions from a urea-fertilised grassland soil and evaluated the nitrification inhibitors dicyandiamide (DCD) and 3,4-dimethylpyrazole phosphate (DMPP). Methods A 28-day soil incubation experiment was conducted using a denitrification incubation system to continuously monitor NO and N2O emissions. In parallel, a destructive incubation experiment was performed to determine the dynamics of ammonium (NH-N) and total oxidised nitrogen (TOxN) and to assess changes in the abundance of AOA and AOB following urea application with or without DCD or DMPP. Results AOA accounted for approximately 66% of the total ammonia-oxidising community. Neither inhibitor significantly affected AOA abundance, whereas both suppressed AOB, with DMPP showing stronger and more persistent inhibition than DCD. DMPP reduced NO emissions by 16 to 75%, whereas N2O emissions decreased by only 0.2 to 27%. The greater reduction in NO, together with the preferential suppression of AOB, suggests that low-abundance AOB contributed disproportionately to NO production despite the numerical dominance of AOA. Conclusions These findings suggest that AOB can contribute disproportionately to NO emissions despite their lower abundance relative to AOA. The preferential suppression of AOB by DMPP was associated with a substantial reduction in NO emissions, highlighting AOB-associated processes as a potential target for mitigating reactive N losses from fertilised soils.

ecology↗

Chromosomal genome assemblies of Antarctic Notothenia coriiceps and temperate relative Paranotothenia angustata

Antarctic notothenioid fish genomes contain evidence of an ancient evolutionary history including their remarkable adaptive radiation beginning [~]10 MYA amid extreme selective pressures of Southern Ocean glaciation. Several Antarctic lineages subsequently escaped and recolonized temperate waters, thus their genomes chronicle the re-adaptation to warmer climates. Here, we report two chromosome-scale genomes assembled from HiFi long reads and Hi-C data for the Antarctic cryonotothenioid Notothenia coriiceps and its secondarily temperate close relative Paranotothenia angustata. The N. coriiceps assembly comprises 11 pseudo-chromosomes, spans 1.12 Gbp with a N90 of 81.48 Mbp and 97.8% gene complete with 24,272 annotated genes. The P. angustata assembly comprises 13 pseudo-chromosomes, spans 1.00 Gbp with a N90 of 62.3 Mbp and 97.9% gene complete with 23,828 annotated genes. We report two new N. coriiceps mitochondrial genome structures, map the antifreeze glycoprotein loci, and corroborate the unusual notothenioid ribosomal RNA gene arrangement. The high-quality assemblies of this species pair provide valuable resources for investigating both the historical evolution of polar fish and their adaptive potential to climate change.

genomics↗

Use of CD122+ natural killer cell precursors for superior anti-leukemia responses.

Acute Myeloid Leukemia (AML) is an aggressive blood cancer in adults. Intensive induction therapy successfully induces a complete response in up to 80% of the adult patients but a fraction of them is refractory or relapses. The fraction of non-responsive or relapsing patients is especially high amongst medically unfit and older patients, who cannot undergo aggressive chemotherapy treatment. Therefore, offering patients failing on first line intensive chemotherapy and medically unfit and older patients an effective treatment option for long-term control or even cure of disease represents a significant yet unmet clinical need. As a component of the innate immunity, NK cells have recently shown great promise for the treatment of patients with different malignancies. Here, we show that injection of human interleukin-2 (IL-2) complexes (IL-2cx) induce the de novo generation and massive expansion of NK cell precursors in vivo. Furthermore, IL-2cx-expanded NK cells exert effector functions with the capacity to control the growth of non-self MHC class I-deficient RMA-S lymphoma cells in vivo, while remaining tolerant towards MHC class-expressing self RMA cells. In an experimental setup mimicking the clinical case of refractory patients after intensive AML induction therapy, IL-2cx treatment mediated strong anti-AML responses following haploidentical bone marrow transplantation without the need for adoptive transfer of donor-derived or in vitro autologous expanded NK cells. Thus, this study demonstrates that IL-2cx immunotherapy allows the in vivo generation and expansion of functionally mature NK cells to achieve long-term response in AML paving the way to an effective treatment option.

immunology↗

Aromatic amino acid biosynthesis by a Lotus Aldolase impacts root hair development and symbiotic associations

O_LILegume roots can be symbiotically colonized by arbuscular mycorrhizal (AM) fungi and nitrogen-fixing bacteria. In Lotus japonicus, the latter occurs intracellularly by the cognate rhizobial partner Mesorhizobium loti or intercellularly with the Agrobacterium pusense IRBG74 strain. Although these symbiotic programs show distinctive cellular and transcriptome signatures, some molecular components are shared. C_LIO_LIIn this study, we demonstrate that Aldolase1, the first enzyme in the biosynthetic pathway of aromatic amino acids (AAA), plays a critical role in root hair development and for AM and rhizobial symbioses in Lotus. C_LIO_LITwo homozygous mutants affected in Aldolase1 (ald1-1 and ald1-2) show drastic alterations in the root hair morphology, associated with a progressive disruption of the actin cytoskeleton. The altered root hair structure was prevented by chemical and genetic complementation. C_LIO_LIBoth ald1-1 and ald1-2 show significant reductions in rhizobial infection (intracellular and intercellular), nodule organogenesis and AM colonization. RNAseq analysis of ald1-2 roots suggested that these phenotypes are associated with downregulation of several cell wall related genes, and with an attenuated symbiotic signalling. This work provides robust evidence that links AAA metabolism to root hair development and successful symbiotic associations. C_LI

plant biology↗