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Bielawski, K.

Publications and source records attributed to Bielawski, K..

2 recordsLinked to original sources

A Closed-Loop Robot Scientist for Autonomous Biological Discovery

Biological systems respond to a wide range of physical inputs and an overarching goal of biological research is understanding how these signaling events coordinate cellular, tissue, and organism-level outcomes. Yet the vast combinatorial space of physical and chemical interventions that influence these processes remains largely unexplored. Thus, a search process is required that efficiently learns how inputs affect a biological target via a series of automatically generated interventions, and a robot scientist that can conduct them. To this end we here introduce the Multimodal Organismal Modulation Robot (MOMbot), a robot scientist that integrates four physical intervention modalities - chemical delivery, electrical field application, mechanical vibration, and thermal modulation -within a single hardware platform. MOMbots multimodal hardware is paired with high-resolution imaging and an online active learning algorithm that autonomously generates, executes, and refines interventions based on accumulated data. We validate the system across biological materials spanning three orders of magnitude in scale, including Xenopus laevis embryos, motile mucociliary organoids, and disaggregated ectodermal stem cells, to show the utility of this approach across diverse biological disciplines. Using these biological models, we demonstrate precise thermal control of embryonic developmental rate, automated chemical perturbation with behavioral readouts, programmable electrical field stimulation, and vibrational assembly of functional mucociliary organoids from loose cells. We also describe the active learning algorithm that autonomously concentrates interventions near regions of maximal outcome uncertainty, yielding sample-efficient discovery of an electrical duration-response relationship for motile organoids. These results establish MOMbot as a scalable robot/AI scientist team for biological discovery, enabling autonomous, multimodal physical experimentation and AI-driven exploration of complex biological systems.

developmental biology↗

Reliable, standardized measurements for cell mechanical properties

Atomic force microscopy (AFM) has become indispensable for studying biological and medical samples. More than two decades of experiments have revealed that cancer cells are softer than healthy cells (for measured cells cultured on stiff substrates). The softness or, more precisely, the larger deformability of cancer cells, primarily independent of cancer types, could be used as a sensitive marker of pathological changes. The wide application of biomechanics in clinics would require designing instruments with specific calibration, data collection, and analysis procedures. For these reasons, such development is, at present, still very limited, hampering the clinical exploitation of mechanical measurements. Here, we propose a standardized operational protocol (SOP), developed within the EU ITN network Phys2BioMed, which allows the detection of the biomechanical properties of living cancer cells regardless of the nanoindentation instruments used (AFMs and other indenters) and the laboratory involved in the research. We standardized the cell cultures, AFM calibration, measurements, and data analysis. This effort resulted in a step-by-step SOP for cell cultures, instrument calibration, measurements, and data analysis, leading to the concordance of the results (Youngs modulus) measured among the six EU laboratories involved. Our results highlight the importance of the SOP in obtaining a reproducible mechanical characterization of cancer cells and paving the way toward exploiting biomechanics for diagnostic purposes in clinics.

biophysics↗