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Berkemeier, F. P.

Publications and source records attributed to Berkemeier, F. P..

2 recordsLinked to original sources

Unifying evolutionary dynamics: a set theory exploration of symmetry and interaction

Within the expansive landscape of evolutionary dynamics, symmetry features embedded in well-established models significantly influence the interpretation of individual interaction patterns. Such symmetries are determined through interaction kernel functions, which serve as mathematical models for characterizing the complexity of interactions between individuals, each with distinct phenotypes. By incorporating analytical tools from logic and set theory, we aim to provide a deeper understanding of these functions, relevant to mechanisms of evolution. We prove that the kernels introduced in Champagnat et al.s unifying framework exist provided birth and death rates are symmetric with respect to non-focal traits. The kernels may nevertheless be highly challenging to construct, thereby indicating a complex underlying mathematical infrastructure within unified evolutionary dynamics. We show how interaction kernels for asymmetric frameworks arising in evolutionary graph theory can be derived by incorporating individuals graph labels into their phenotypes. These insights invite new avenues for research, providing a fresh understanding of the interactions between individuals in broader biological contexts.

evolutionary biology↗

Coupling dynamics of 2D Notch-Delta signalling

Understanding pattern formation driven by cell-cell interactions has been a significant theme in cellular biology for many years. In particular, due to their implications within many biological contexts, lateral-inhibition mechanisms present in the Notch-Delta signalling pathway led to an extensive discussion between biologists and mathematicians. Deterministic and stochastic models have been developed as a consequence of this discussion, some of which address long-range signalling by considering cell protrusions reaching non-neighbouring cells. The dynamics of such signalling systems reveal intricate properties of the coupling terms involved in these models. In this work, we examine the benefits and limitations of new and existing models of cell signalling and differentiation in a variety of contexts. Using linear and weakly nonlinear stability analyses, we find that pattern selection relies on nonlinear effects that are not covered by such analytical methods.

developmental biology↗