bioRxiv Science⌕ Search

Biology subjects

Beliaeva, V.

Publications and source records attributed to Beliaeva, V..

2 recordsLinked to original sources
bioRxiv2023

Multipair phase-modulated temporal interference electrical stimulation combined with fMRI.

Temporal Interference stimulation (TIS) is a promising non-invasive brain stimulation technique exploiting frequency-shifted kHz fields to modulate oscillatory neural activity without invasive procedures. While human studies suggest TIS efficacy in targeting relatively deep brain structures, recent computational modeling and animal studies indicate potential off-target stimulations via the application of standard TIS protocols. Here, we computationally optimized TIS targeting for the prefrontal cortex (PFC) in mice. Combining in vivo electrophysiological recordings, intracellular calcium dynamics with fiber photometry, and functional MRI, we confirmed TIS-induced amplitude modulation, neuronal entrainment and hemodynamic responses in the PFC, while also identifying off-target modulations. To mitigate off-target effects, we propose a novel configuration with three electrode pairs, one of which is actively phase-shifted by 180 degrees. This cancelling field significantly enhanced TIS focality, reducing off-target effects without compromising the TIS efficacy in the target area. This work effectively addresses one of TIS most critical shortcomings and opens new avenues for research and clinical applications. O_FIG O_LINKSMALLFIG WIDTH=200 HEIGHT=178 SRC="FIGDIR/small/571679v2_ufig1.gif" ALT="Figure 1"> View larger version (40K): org.highwire.dtl.DTLVardef@b04067org.highwire.dtl.DTLVardef@154549aorg.highwire.dtl.DTLVardef@17e63c3org.highwire.dtl.DTLVardef@c7a341_HPS_FORMAT_FIGEXP M_FIG C_FIG

neuroscience↗
bioRxiv2022

LTP-like noninvasive striatal brain stimulation enhances striatal activity and motor skill learning in humans

The stimulation of deep brain structures has thus far only been possible with invasive methods. Transcranial electrical temporal interference stimulation (tTIS) is a novel, noninvasive technology that might overcome this limitation. The initial proof-of-concept was obtained through modeling, physics experiments and rodent models. Here, we show for the first time successful noninvasive neuromodulation of the striatum via tTIS in humans using computational modeling, fMRI studies and behavioral evaluations. Theta-burst patterned striatal tTIS increased activity in the striatum and associated motor network. Furthermore, striatal tTIS enhanced motor performance, especially in healthy older participants as they have lower natural learning skills than younger subjects. These findings place tTIS as exciting new method to target deep brain structures in humans noninvasively, thus enhancing our understanding of their functional roles. Moreover, our results lay the groundwork for innovative, noninvasive treatment strategies for brain disorders in which deep striatal structures play key pathophysiological roles.

neuroscience↗