Beerlage-de Jong, N. | bioRxiv Science

bioRxiv2021

The Visual Dictionary of Antimicrobial Stewardship, Infection Control, and Institutional Surveillance

ObjectivesData and data visualization are integral parts of (clinical) decision-making in general and stewardship (antimicrobial stewardship, infection control, and institutional surveillance) in particular. However, systematic research on the use of data visualization in stewardship is lacking. This study aimed at filling this gap by creating a visual dictionary of stewardship through an assessment of data visualization in stewardship research. MethodsA random sample of 150 data visualizations from published research articles on stewardship were assessed. The visualization vocabulary (content) and design space (design elements) were combined to create a visual dictionary. Additionally, visualization errors, chart junk, and quality were assessed to identify problems in current visualizations and to provide improvement recommendations. ResultsDespite a heterogeneous use of data visualization, distinct combinations of graphical elements to reflect stewardship data were identified. In general, bar (n=54; 36.0%) and line charts (n=42; 28.1%) were preferred visualization types. Visualization problems comprised colour scheme mismatches, double y-axis, hidden data points through overlaps, and chart junk. Recommendations were derived that can help to clarify visual communication, improve colour use for grouping/stratifying, improve the display of magnitude, and match visualizations to scientific standards. ConclusionsResults of this study can be used to guide data visualization creators in designing visualizations that fit the data and visual habits of the stewardship target audience. Additionally, the results can provide the basis to further expand the visual dictionary of stewardship towards more effective visualizations that improve data insights, knowledge, and clinical decision-making.

scientific communication and education↗

bioRxiv2021

Mapping Twenty Years of Antimicrobial Resistance Research Trends

BackgroundAntimicrobial resistance (AMR) is a global threat to health and healthcare. In response to the growing AMR burden, research funding also increased. However, a comprehensive overview of the research output, including conceptual, temporal, and geographical trends, is missing. Therefore, this study uses topic modelling, a machine learning approach, to reveal the scientific evolution of AMR research and its trends, and provides an interactive user interface for further analyses. MethodsStructural topic modelling (STM) was applied on a text corpus resulting from a PubMed query comprising AMR articles (1999-2018). A topic network was established and topic trends were analysed by frequency, proportion, and importance over time and space. FindingsIn total, 88 topics were identified in 158616 articles from 166 countries. AMR publications increased by 450% between 1999 and 2018, emphasizing the vibrancy of the field. Prominent topics in 2018 were Strategies for emerging resistances and diseases, Nanoparticles, and Stewardship. Emerging topics included Water and environment, and Sequencing. Geographical trends showed prominence of Multidrug-resistant tuberculosis (MDR-TB) in the WHO African Region, corresponding with the MDR-TB burden. China and India were growing contributors in recent years, following the United States of America as overall lead contributor. InterpretationThis study provides a comprehensive overview of the AMR research output thereby revealing the AMR research response to the increased AMR burden. Both the results and the publicly available interactive database serve as a base to inform and optimise future research. FundingINTERREG-VA EurHealth-1Health (202085); European Commission Horizon 2020 Framework Research in contextO_ST_ABSEvidence before this studyC_ST_ABSPrior to this study, PubMed, Web of Science, Scopus, and IEEE Xplore were queried to find studies providing a conceptual overview of antimicrobial resistance (AMR) research over time and space. The search string included keywords ("antimicrobial" OR antibiotic*) AND (resistan*) AND ("science mapping" OR bibliometric OR scientometric) in the title and abstract and focused on articles published before 2019 without language restrictions. Few studies were found relying on scientometric and bibliometric methods to assess either subfields of AMR research (e.g., AMR among uropathogens) or AMR-related fields (e.g., microbiology). No studies were found that focus on the entire AMR field. Therefore, this science mapping study using topic modelling was performed to provide an overview of the AMR field by identifying and assessing topics, trends, and geographical differences over time. Added value of this studyTo the best of our knowledge, this study is the first to use a science mapping approach to provide a comprehensive overview of the entire AMR research field, covering over 150 thousand articles published between 1999 and 2018. Our findings revealed important (e.g., Strategies for emerging resistances and diseases, Nanoparticles, and Stewardship) and emerging (e.g., Water and environment, and Sequencing) topics in AMR research. Lastly, this study resulted in an interactive user interface where all data are presented for further analyses. Implications of all the available evidenceOur comprehensive overview of the AMR field, including its conceptual structure, and temporal and geographical trends revealed the response of the research community to the AMR burden. The results and the openly available supporting data provide the base to guide future funding and research directions to tackle AMR.

microbiology↗