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Biology subjects

Bean, D.

Publications and source records attributed to Bean, D..

2 recordsLinked to original sources

Network analysis of patient flow in two UK acute care hospitals identifies key sub-networks for A&E performance

The topology of the patient flow network in a hospital is complex, comprising hundreds of overlapping patient journeys, and is a determinant of operational efficiency. To understand the network architecture of patient flow, we performed a data-driven network analysis of patient flow through two acute hospital sites of Kings College Hospital NHS Foundation Trust. Administration databases were queried for all intra-hospital patient transfers in an 18-month period and modelled as a dynamic weighted directed graph. A core subnetwork containing only 13-17% of all edges channelled 83-90% of the patient flow, while an ephemeral network constituted the remainder. Unsupervised cluster analysis and differential network analysis identified sub-networks where traffic is most associated with A&E performance the following day. Increased flow to clinical decision units was associated with the best A&E performance in both sites. The component analysis also detected a weekend effect on patient transfers which was not associated with performance. We have performed the first data-driven hypothesis-free analysis of patient flow which can enhance understanding of whole healthcare systems. Such analysis can drive transformation in healthcare as it has in industries such as manufacturing.

bioinformatics

Hybridization affects life-history traits and host specificity in Diorhabda spp.

Hybridization is an influential evolutionary process that has been viewed alternatively as an evolutionary dead-end or as an important creative evolutionary force. In colonizing species, such as introduced biological control agents, hybridization can negate the effects of bottlenecks and genetic drift through increasing genetic variation. Such changes could be beneficial to a biological control program by increasing the chances of establishment success. However, hybridization can also lead to the emergence of transgressive phenotypes that could alter host specificity; an important consideration when assessing potential non-target impacts of planned agents. In a series of lab experiments, we investigated the effects of hybridization between three species of Diorhabda released to control invasive Tamarix (saltcedar) on life history traits through two generations, and through the third generation for one cross. Depending on the cross, hybridization had either a positive or neutral impact on development time, adult mass, and fecundity. We evaluated preference for the target (saltcedar) relative to a non-target host Tamarixaphylla (athel), and found host specificity patterns varied in two of the three hybrids, demonstrating the possibility for hybridization to alter host preference. Importantly, the overall effects of hybridization were inconsistent by cross, leading to unpredictability in the outcome of using hybrids in biological control.

ecology