Biology subjects

Bakhit, M.

Publications and source records attributed to Bakhit, M..

2 recordsLinked to original sources

bioRxiv2020

The Superior Frontal Longitudinal Tract: Connection between the Dorsal Premotor and the Dorsolateral Prefrontal Cortices

The structural connection between the dorsal premotor (PMd) and the lateral prefrontal cortices (DLPFC) has been revealed, in a few studies, as the frontal longitudinal system (FLS). This study conducted a tractography analysis and a limited, postmortem, white-fiber dissection to investigate the superior FLS tract (SFLT) and analyze both its symmetry and termination point patterns. An analysis of spatial location, termination points, laterality, and correlation with the subjects gender or handedness was performed. SFLT was constructed in 100% of right and 88% of left hemispheres. The tracts exhibited variable patterns in different subjects in their posterior terminations. Additionally, the SFLT was found to possess a complex spatial relationship with the adjacent bundles. The SFLT was revealed successfully in two right hemispheres, where the posterior terminations were found to originate in the PMd, and its posterior terminations being totally separate from the superior longitudinal fasciculus.

neuroscience↗

bioRxiv2018

Skull base invasive low-grade meningiomas, a distinct genetic subgroup: A microarray gene expression profile analysis.

IntroductionMeningioma is the most common adult primary brain tumor originating from meningeal coverings of the brain and spinal cord. Commonly, World Health Organization (WHO) grade-I meningiomas are slowly growing and surgically curative, some present with clinically aggressive behavior, invading the skull base bone and soft tissues by extending into the extracranial spaces.\n\nMethodsTo detect the genetic background of the Skull Base Invasive Low-grade Meningioma (SBILM), we conducted a comprehensive analysis of gene expression was conducted on 32 meningioma samples.\n\nResultsThe cluster analysis of the gene expression profile demonstrated a distinctive clustering pattern of the SBILM. Based on the clinical behavior and the microarray findings, they might be a distinct subgroup of meningiomas.\n\nConclusionFurther studies on characterization of genes specifically expressed by the SBILM could lead to the development of diagnostic tools, differentiating it from other WHO grade-I meningiomas and assist in the appropriate management and follow-up strategy, and open the door for development of pharmacological therapies.

genomics↗