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Bacon, J. B.

Publications and source records attributed to Bacon, J. B..

2 recordsLinked to original sources

Open-Source Framework for Measurement of the Gradient Impulse Response Function

The Gradient Impulse Response Function (GIRF) is widely used to model and correct gradient system imperfections in MRI, but scanner-specific GIRF measurement remains inaccessible to many research groups because existing approaches rely on specialised field monitoring hardware or fragmented and non-reproducible software workflows. To address this limitation, an open-source, end-to-end framework for phantom-based GIRF measurement is presented, providing a reproducible workflow requiring only standard MRI hardware and a spherical water phantom. The framework integrates vendor-independent pulse sequence generation, phantom-based data acquisition, automated data processing, and GIRF estimation. The framework was validated by comparing GIRF-predicted non-Cartesian k-space trajectories with independent measurements acquired using NMR field probes, which served as the gold-standard for trajectory characterization. Accurate prediction of rosette and spiral trajectories was demonstrated across multiple imaging orientations, with substantially lower trajectory error than the corresponding nominal trajectories. By providing the first openly available end-to-end implementation for phantom-based GIRF measurement, the barrier to routine scanner-specific GIRF characterisation is reduced, facilitating broader adoption of GIRF-based methods across the MRI community.

bioengineering↗

MR Spectroscopy without Water Suppression using the Gradient Impulse Response Function

PurposeNon-water-suppressed proton spectroscopy, 1H-MRS, is desirable, as retaining the strong water resonance can facilitate automated online data corrections, internal concentration referencing, and monitoring of line narrowing effects in functional MRS. Removal of the water suppression module can also mitigate magnetization transfer effects and slightly reduce the minimum achievable TR and total RF power deposition. However, water suppression is typically considered essential due to eddy current-induced antisymmetric sidebands on the water resonance that distort the spectral baseline and obscure metabolite signals. Theory and MethodsThe Gradient Impulse Response Function (GIRF) was used to predict time-dependent magnetic field perturbations during the FID that generate the artefactual sidebands. The GIRF was measured in a one-time calibration, independent of spectroscopy acquisitions, enabling post-processing correction of the sidebands without sequence modification or additional dedicated hardware. GIRF-corrected non-water-suppressed single-voxel-spectroscopy (SVS) was compared to otherwise identical water-suppressed acquisitions in eight participants at 3T using semi-LASER and MEGA-PRESS sequences. ResultsAcross participants, GIRF correction reduced sideband amplitudes to levels comparable with the spectral baseline, enabling recovery of the underlying metabolite signals. Systematic increases in quantified metabolite concentrations were observed relative to water-suppressed acquisitions, consistent with water-suppression-induced magnetization transfer effects. Total creatine exhibited the largest increase, with enhancement ratios of 1.069{+/-}0.039 for MEGA-PRESS and 1.535{+/-}0.160 for semi-LASER acquisitions. ConclusionGradient-induced artefactual sidebands in non-water-suppressed MR spectroscopy can be effectively corrected using the GIRF to predict time-dependent magnetic field perturbations during the FID. In principle, the approach extends to other SVS sequences and field strengths following appropriate GIRF calibration.

bioengineering↗