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Biology subjects

Asmare, Y.

Publications and source records attributed to Asmare, Y..

2 recordsLinked to original sources
bioRxiv2019

Prevalence of Alcohol use during pregnancy and its association with partner alcohol use in East Africa: systematic review and meta-analysis

Introductionmaternal alcohol beverages consumption (any amount) during pregnancy can result in multiple major health and social problems both for the mother and fetus; including miscarriage, stillbirth, low birth weight, and prematurity. At the regional and national level, alcohol use prevalence data is a use full indicator for maternal and child health.\n\nMethodsthe researchers were searched for studies using a computerized search engine, main electronic databases, and other applicable sources. Observational studies (case-control, crosssectional and cohort) which assess the prevalence of alcohol use and associated factors among pregnant mothers in East Africa were eligible. Data was extracted thoroughly by two authors independently and screened for eligibility. The Pooled prevalence of alcohol use during pregnancy and its association with partner alcohol use was determined by using Epi data version 14 statistical software.\n\nResultsthe study included eighteen studies with the total sample size of 41,022 and The overall pooled prevalence of alcohol use during pregnancy from the random effects method was found to be 18.85% (95% CI; 11.26, 26.44). The overall weighted odds ration revealed that pregnant women partners alcohol use did not have a significant association with study subjects alcohol use during pregnancy; i.e. OR=0.32 (95% CI: -0.39, 1.03).\n\nConclusionsThe overall alcohol use (any amount) during pregnancy is higher in magnitude and pregnant mothers who had alcohol user partner had no association with their use of alcohol beverages. The prevalence of alcohol use during pregnancy may be underestimated in the current study due to social desirability bias. Since related study articles were found only in four East African countries, the region may be under-represented due to the limited number of studies included.

pharmacology and toxicology↗
bioRxiv2019

Survival status and predictors of mortality among Breast cancer patients at Black lion specialized hospital, Adult oncology unit, Addis Ababa, Ethiopia, 2018. A retrospective follow-up study with survival analysis

IntroductionBreast cancer is a foremost cause of death worldwide, ranks fifth among causes of death from all types of cancers; this is the most common cause of cancer death in women among both developing and developed countries. Breast cancer ranks first among most frequent cancers in women of Ethiopia. In spite of the high incidence, mortality rate, and survival status among breast cancer patients was not determined in Ethiopia.\n\nObjectiveThe main aim of the study is to assess the survival status and predictor the mortality among Breast Cancer patients in Adult Oncology Unit at Black Lion Specialized Hospital in 2018.\n\nMethodsAn institution based retrospective follow up study was conducted in Adult Oncology Unit at Black Lion Specialized Hospital. All cases of breast cancer registered from 1st January 2012 to 31th December,2014 were followed for the six-year survival (until 31th December, 2017). Kaplan-Meier survival curve together with log rank test was deployed to test for variations in the survival among predictor variables. Cox regression was used at 5% level of significance to determine the net effect of each independent variable on time to death of breast cancer clients.\n\nResultsThe results indicate that the incidence rate of mortality was 9.8 per 100 person/ years (95% CI: 8.49-11.47).The overall median survival time was 56.5(95% CI (53.46 - 60.83)) months. The overall estimated survival rate was recorded 27% (95% CI, 17.09 to 36.67 %) at 72 months of follow up, whereas at odd years (1, 3, and 5 years) were, 97.2%, 80.8%, and 46.2% respectively. Predictors of mortality were assessed at clinical stage (III&IV),(AHR =1.86), poorly differentiated histology (AHR: 3.1) & positive lymph node status (AHR:3.13),Whereas adjuvant hormone therapy (AHR: 0.67) and chemotherapy (AHR:0.72) were protective.\n\nConclusionThe overall probability of survival in Ethiopia was inferior when compared with other high and middle-income countries. Predictors of mortality were at advanced clinical stage, poorly differentiated histology grade, surgical margin involvement and positive lymph node status. In contrary, adjuvant hormone therapy, modified radical mastectomy and chemotherapy were protective factors. Hence, special emphasis could be given to early screening, stage diagnosis and initiation of treatment.

epidemiology↗