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Biology subjects

Appiah, E.

Publications and source records attributed to Appiah, E..

2 recordsLinked to original sources

Hybrid Deep Learning and Lee-Carter Model for Mortality Forecasting: A Study of US Adults Aged 35-80

This study introduces a hybrid approach that enhances mortality forecasts by integrating machine learning techniques specifically Long Short-Term Memory (LSTM), Bidirectional LSTM (BiLSTM), and Neural Networks (NN) with the traditional Lee-Carter model. After deriving the time index{kappa} t from the Lee-Carter model, these deep learning models were employed to capture complex temporal patterns, which were then incorporated into the Lee-Carter frame-work to improve forecasting accuracy. The hybrid models were evaluated using historical mortality data from the United States, covering ages 35 to 80 years from 1975 to 2020. Among the models tested, the LSTM model outperformed all others, demonstrating superior capability in capturing time dependencies and producing more accurate mortality forecasts. The integration of LSTM with the Lee-Carter framework led to significant improvements in predictive accuracy. This research demonstrates that combining traditional statistical approaches with modern deep learning techniques, particularly LSTM, offers a powerful method for enhancing mortality forecasting by effectively modeling time-dependent patterns. These findings provide valuable insights and tools for policymakers, actuaries, and healthcare professionals to improve planning and decision-making.

bioinformatics↗

Bisphenol S moderately decreases the expression of syncytiotrophoblast marker genes and induces apoptosis in human trophoblast lineages.

Bisphenol S (BPS) is currently used in the manufacturing of several household equipment such as water pipes and food containers. Hence, its entrance into the human body is almost inevitable. The presence of BPS in body fluids has been reported. However, its potential toxicity, especially on human placenta development and pregnancy progression, has not been explored. In this study, we assessed the impacts of BPS on self-renewal and differentiation potentials of placental stem cells, also known as trophoblast stem cells (TSCs), by exposing them to three different BPS concentrations during both self-renewal and differentiation of TSCs into syncytiotrophoblast (ST), extravillous trophoblast (EVT), and trophoblast organoids. Interestingly, BPS treatment did not affect the stemness, cell cycle and proliferation of the TSCs but it induced apoptosis in each trophoblast lineage. BPS altered the expression of several fusion-related genes. However, this alteration did not translate into significant morphological defects in the STs and organoids. Moreover, BPS did not impair the differentiation of TSCs into EVTs. These findings suggest that the presence of BPS at the feto-maternal interface may exaggerate trophoblast apoptosis and moderately inhibit the trophoblast fusion pathway to affect placenta development and pregnancy. Our study offers valuable insights into the potential toxicity of BPS on human placenta development, emphasizing the need for epidemiological assessment of the relationship between maternal serum levels of BPS and pregnancy complications.

pharmacology and toxicology↗