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Anil, S.

Publications and source records attributed to Anil, S..

2 recordsLinked to original sources

Fusing multisensory signals across channels and time

Animals continuously combine information across sensory modalities and time, and use these combined signals to guide their behaviour. Picture a predator watching their prey sprint and screech through a field. To date, a range of multisensory algorithms have been proposed to model this process including linear and nonlinear fusion, which combine the inputs from multiple sensory channels via either a sum or nonlinear function. However, many multisensory algorithms treat successive observations independently, and so cannot leverage the temporal structure inherent to naturalistic stimuli. To investigate this, we introduce a novel multisensory task in which we provide the same number of task-relevant signals per trial but vary how this information is presented: from many short bursts to a few long sequences. We demonstrate that multisensory algorithms that treat different time steps as independent, perform sub-optimally on this task. However, simply augmenting these algorithms to integrate across sensory channels and short temporal windows allows them to perform surprisingly well, and comparably to fully recurrent neural networks. Overall, our work: highlights the benefits of fusing multisensory information across channels and time, shows that small increases in circuit/model complexity can lead to significant gains in performance, and provides a novel multisensory task for testing the relevance of this in biological systems. 1 Author summaryWe constantly detect sensory inputs, like sights and sounds, and use combinations of these signals to guide our actions. For example, by reading someones lips we can better converse with them in a noisy environment. Several mathematical models have been proposed to describe this process. However, these models are "blind" to time. That is, following the example above, if we took the audio and visual signals from our friend and mixed them up over time; current models would not notice any difference, but we would find the result incomprehensible. Motivated by this, we introduce a new set of models which describe how animals could fuse sensory signals across time. Surprisingly, we find that combining signals across senses and short periods of time, works as well as a more complex model. 2 Key PointsO_LIWe introduce a novel multisensory task in which we provide task relevant evidence via bursts of varying duration, amidst a noisy background. C_LIO_LIPrior multisensory algorithms perform sub-optimally on this task, as they cannot leverage temporal structure. C_LIO_LIHowever, they can perform better by integrating across sensory channels and short temporal windows. C_LIO_LISurprisingly, this allows for comparable performance to fully recurrent neural networks, while using less than one tenth the number of parameters. C_LI

neuroscience↗

Repetitive transcranial magnetic stimulation (rTMS) triggers dose-dependent homeostatic rewiring in recurrent neuronal networks

Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive brain stimulation technique used to induce neuronal plasticity in healthy individuals and patients. Designing effective and reproducible rTMS protocols poses a major challenge in the field as the underlying biomechanisms remain elusive. Current clinical protocol designs are often based on studies reporting rTMS-induced long-term potentiation or depression of synaptic transmission. Herein, we employed computational modeling to explore the effects of rTMS on long-term structural plasticity and changes in network connectivity. We simulated a recurrent neuronal network with homeostatic structural plasticity between excitatory neurons, and demonstrated that this mechanism was sensitive to specific parameters of the stimulation protocol (i.e., frequency, intensity, and duration of stimulation). The feedback-inhibition initiated by network stimulation influenced the net stimulation outcome and hindered the rTMS-induced homeostatic structural plasticity, highlighting the role of inhibitory networks. These findings suggest a novel mechanism for the lasting effects of rTMS, i.e., rTMS-induced homeostatic structural plasticity, and highlight the importance of network inhibition in careful protocol design, standardization, and optimization of stimulation. Author summaryThe cellular and molecular mechanisms of clinically employed repetitive transcranial magnetic stimulation (rTMS) protocols remain not well understood. However, it is clear that stimulation outcomes depend heavily on protocol designs. Current protocol designs are mainly based on experimental studies that explored functional synaptic plasticity, such as long-term potentiation of excitatory neurotransmission. Using a computational approach, we sought to address the dose-dependent effects of rTMS on the structural remodeling of stimulated and non-stimulated connected networks. Our results suggest a new mechanism of action--activity-dependent homeostatic structural remodeling--through which rTMS may assert its lasting effects on neuronal networks. We showed that the effect of rTMS on structural plasticity critically depends on stimulation intensity, frequency, and duration and that recurrent inhibition can affect the outcome of rTMS-induced homeostatic structural plasticity. These findings emphasize the use of computational approaches for an optimized rTMS protocol design, which may support the development of more effective rTMS-based therapies.

neuroscience↗