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Amano, K.

Publications and source records attributed to Amano, K..

At least 19 recordsLinked to original sources

Subspace Image Synthesis for Style-Invariant Object Recognition

Human-like behavior in visual models does not necessarily imply human-like internal computation. When a model recognizes objects robustly across changes in visual style, what internal computations support this behavior, and which are relevant to human perception? We addressed this question by pruning style-robust neural networks into candidate submodels corresponding to two computational strategies. The first retained channels whose responses were stable across style changes for fixed content, yielding a Content Stability Score (CSS)-based submodel. The second retained channels whose responses were stable across content changes for fixed style, yielding a Style Stability Score (SSS)-based submodel. Across ImageNet, Stylized ImageNet, and model-versus-human benchmarks, the two submodel families showed comparable object-recognition performance. We then used their exclusive feature subspaces to generate matched images with Gram-matrix-based neural style transfer and asked human observers which image was more similar in visual style to a reference image. Images generated from the CSS-based submodel were selected significantly more often than chance, even though CSS preferentially retained channels whose individual activation patterns were relatively insensitive to style. These results suggest that representations preserving content across style changes are more consistent with human judgments of visual style. More broadly, they demonstrate a framework for isolating candidate computational subspaces from large artificial models and testing their perceptual relevance through image synthesis.

neuroscience↗

Task-general brain state dynamics relate to trial-to-trial performance and individual response strategy

Behavior fluctuates from moment to moment, yet individuals also show characteristic response strategies across tasks. Whether these two levels of variation relate to common brain dynamics is unknown. Using an inside-out approach across 10 cognitive tasks during fMRI, we identified recurring brain states and related their dynamics to behavior within and between individuals. Default mode network (DMN) dominant and action mode network (AMN) dominant states occurred in all tasks. Within individuals, momentary state identity (the state occupied at a given moment) tracked trial-to-trial performance. The AMN-dominant state was associated with slower, more variable responses across tasks, whereas its relationship to accuracy depended on the task. Across individuals, switching between the two states, but not time spent in either, showed cross-task consistency, and frequent switchers showed faster, less accurate responding. Thus, distinct aspects of the same task-general brain state dynamics, momentary state identity and state switching, relate to behavior at both levels.

neuroscience↗

Probing the content of semantic representations in body-selective regions

The extrastriate body area (EBA) has been known to selectively respond to human body parts, but recent work suggests it may encode richer scene semantics. However, it remains unclear what aspects of natural scenes constitute the semantic representation in the EBA. Here we address this question by analyzing the relationship between object co-occurrence in natural scene captions and EBA responses predicted by caption-based encoding models. This revealed object category pairs associated with EBA activity, leading to the hypothesis that EBA encodes the speed of human body motion implied in scenes. A subsequent behavioral experiment and correlation analyses confirmed this, showing strong correlations between EBA responses and implied motion ratings. In addition, the representation of implied body motion extends into the fusiform body area (FBA). Variance partitioning further showed that while body-related features such as the number of people and body size also contributed, implied motion uniquely explained the largest portion of EBA and FBA responses. Overall, semantic representations in body-selective regions are jointly shaped by multiple body-related features, with implied motion as the primary contributor. Our co-occurrence-based approach, combined with brain-to-model mapping methods, offers a novel, interpretable framework for understanding high-level visual representations in natural scene perception.

neuroscience↗

Transcranial electrical stimulation for memory enhancement: A systematic review and meta-analysis

BackgroundNon-invasive brain stimulation techniques have received increasing interest for their potential to enhance memory function, a fundamental cognitive aspect of daily life. MethodsThis systematic review and meta-analysis investigated the efficacy of transcranial electrical stimulation (tES) in enhancing memory function in healthy adults, following the pre-registered strategy at PROSPERO (CRD42022353630). ResultsA total of 66 articles (119 trials, 3,786 participants) focusing on transcranial direct current stimulation and transcranial alternating current stimulation were identified. Meta-analysis revealed a significant overall effect of tES on memory function compared with sham stimulation (standardized mean difference [95% confidence interval] = 0.19 [0.12-0.27]), with anodal transcranial direct current stimulation showing the most consistent enhancement. In particular, stimulation of the frontal regions effectively improved working and declarative memories. While the effects remained significant within hours post-stimulation, they diminished after one day or longer. Regarding adverse events, tingling and itching sensations on the scalp occurred more frequently in the active group than in the sham group, but no severe adverse events were reported. Challenges, including publication bias, heterogeneity, and bias toward specific aspects of memory were noted, emphasizing the need for improved experimental rigor and diversification of memory tasks. ConclusionThese findings highlight the potential of tES as a safe and effective tool for memory enhancement while emphasizing areas for future research to develop its applications.

neuroscience↗

Preprints vs. Journal Articles: Citation Impact in COVID-19 Research

Focusing on article and citation count, this study examined 110 academic journals whose papers on COVID-19 were indexed in PubMed from 2020 to 2023. To analyze these journals characteristics, this study introduced the concepts of paper ratio, citation ratio, and citation impact. Journals with similar trends in paper and citation count were positioned near the diagonal on a two-dimensional graph (y=x) with paper ratio on the x-axis and citation ratio on the y-axis, indicating a slope close to 1. Conversely, the greater the disparity between paper ratio and citation ratio, the wider the angle between the journals position and the diagonal. Of the 110 journals in 2020, 83 were above the diagonal with a citation impact greater than 1, while 27 were below the diagonal with a citation impact of 1 or lower. Notably, nine journals--BMC Health Services Research, Genome Medicine, Nature, Annals of Epidemiology, BMC Bioinformatics, Nature Microbiology, PLoS Computational Biology, Medicine (Baltimore), and Journal of Clinical Investigation--showed high citation impact, with preprint-distributed papers being cited nearly five times more than directly submitted papers. This study demonstrates that articles initially distributed as preprints in these journals tend to receive substantially more citations than directly submitted ones.

scientific communication and education↗

Single cone photoreceptors experience global image statistics through gaze shifts

Our visual experience does not merely reflect a static view of the world but is a dynamic consequence of our actions, most notably our continuously shifting gaze. These shifts determine the spectral diet of any individual cone photoreceptor. The aim of this study was to characterize that diet and its relationship to scene adaptation. Gaze shifts were recorded from observers freely viewing scenes outdoors for five minutes. Hyperspectral images of the scenes were also recorded from the observers eye position. As a control, gaze shifts were also recorded from observers viewing the images on a computer-controlled display in the laboratory. From the hyperspectral data, spatially local histograms of estimated excitations in long-, medium-, and short-wavelength-sensitive cones were accumulated over time at different retinal locations. A global illuminant change was then introduced to test how well local retinal adaptation discounted its effects. The results suggest that over short periods individual cones tend to experience the statistics of full scenes, with local adaptation compensating for illumination changes almost as well as global adaptation. This compensation may help to maintain our stable local perception of scene colour despite changes in scene illumination.

neuroscience↗

Neural Mechanisms of Feedback Processing and Behavioral Adaptation during Neurofeedback Training

The acquisition of new skills is facilitated by providing individuals with feedback that reflects their performance. This process creates a closed loop that involves feedback processing and regulation recalibration to promote effective training. Functional magnetic resonance imaging (fMRI)-based neurofeedback is unique in applying this principle by delivering direct feedback on the self-regulation of brain activity. Understanding how feedback-driven learning occurs requires examining how feedback is evaluated and how regulation adjusts in response to feedback signals. In this pre-registered mega-analysis, we re-analyzed data from eight intermittent fMRI neurofeedback studies (N = 153 individuals) to investigate brain regions where activity and connectivity are linked to feedback processing and regulation recalibration (i.e., regulation after feedback) during training. We harmonized feedback scores presented during training in these studies and computed their linear associations with brain activity and connectivity using parametric general linear model analyses. We observed that, during feedback processing, feedback scores were positively associated with (1) activity in the reward system, dorsal attention network, default mode network, and cerebellum; and with (2) reward system-related connectivity within the salience network. During regulation recalibration, no significant associations were observed between feedback scores and either activity or associative learning-related connectivity. Our results suggest that neurofeedback is processed in the reward system, supporting the theory that reinforcement learning shapes this form of brain training. In addition, the involvement of large-scale networks in feedback processing, continuously transitioning between evaluating external feedback and internally assessing the adopted cognitive state, suggests that higher-level processing is integral to this type of learning. Our findings highlight the pivotal role of performance-related feedback as a driving force in learning, potentially extending beyond neurofeedback training to other feedback-based processes. Key PointsWe conducted a pre-registered mega-analysis integrating data from eight fMRI neurofeedback studies to examine feedback processing and regulation recalibration during neurofeedback training. During feedback processing, feedback was associated with activity in the reward system, dorsal attention network, default mode network, and cerebellum; as well as with reward system-related connectivity within the salience network. We found no positive results during regulation blocks; however, additional analyses suggest that recalibration may have already occurred during feedback presentation.

neuroscience↗

The Impact of Preprints on the Citations of Journal Articles Related to COVID-19

To investigate the impact of preprints on the citation counts of COVID-19-related papers, this study compares the number of citations received by drafts initially distributed as preprints and later published in journals with those received by papers directly submitted to journals. The difference in the median number of citations between COVID-19 preprint-distributed papers and COVID-19 directly submitted papers published in 184 journals was tested using the Mann-Whitney U test. The results showed that 129 journals had a statistically significant higher median citation count for COVID-19 preprint-distributed papers compared to directly submitted papers, with a p-value of less than 0.05. In contrast, no journals had a statistically significant higher median citation count for COVID-19 directly submitted papers. This indicates that 70.11% of the journals that published preprint-distributed papers experienced a significant increase in citations. We also identified that among the 184 journals, 13 journals garnered a substantial number of citations. Among the 74,037 COVID-19 papers, preprint-distributed papers (9,028) accounted for only 12.19%. However, among the 2,015,997 citations received by COVID-19 papers, preprint-distributed papers garnered 542,715 citations, representing a substantial 26.92%. These results suggest that distributing preprints prior to formal publication may help COVID-19 research reach a wider audience, potentially leading to increased readership and citations.

scientific communication and education↗

The Impact of Preprints on COVID-19 Research Dissemination: A Quantitative Analysis of Journal Publications

Preprints have played an unprecedented role in disseminating COVID-19-related science results to the public. The study aims to elucidate the role of preprints during the COVID-19 public health emergency (2020-2023) through a quantitative analysis of journal papers. Among the 247,854 COVID-19-related papers published in PubMed, 12,152 were initially released as preprints and were eventually published in 1,380 journals. This number is more than five times the 246 journals to which submissions can be made directly from bioRxiv through the B2J program. Journals with higher impact factors and Normalized Eigenfactor scores tend to publish a larger number of preprint-derived articles. The proportion of preprints among PubMed papers was 0.049, but this varies significantly by journal. In the top 30 journals, most exceed this proportion, indicating that these journals are preferred by authors for submitting their work. These findings highlight the growing acceptance and impact of preprints in the scientific community, particularly in high-impact journals.

scientific communication and education↗

Electroencephalographic Biomarkers of Relaxation: A Systematic Review and Meta-analysis

The human electroencephalogram (EEG) is composed of synchronous oscillations within characteristic frequency bands, including 8-13 Hz alpha oscillations that often appear during relaxation. Relaxation is critical for physical and mental health, but the extent to which various EEG components reflect relaxation remains uncertain. This systematic review and meta-analysis investigated associations between EEG components and concurrently measured reference indices of relaxation in healthy adults. A comprehensive database search and screening using preset criteria identified 38 studies involving 1,120 participants published between January 1940 and January 2022 for qualitative synthesis. These studies used various reference relaxation measures such as electrocardiographic indices related to parasympathetic nervous system activity and introspective indices obtained through questionnaires. Risks of bias were evaluated following the risk of bias assessment tool for nonrandomized studies. A meta-analysis of 23 studies using a random-effects model revealed positive correlations between relaxation index and the power of alpha oscillations at central channels (Fishers z-transformed correlation coefficient and [95% confidence interval]: 0.23 [0.10-0.36]) and frontal channels (0.16 [0.02-0.31]). The correlation was significantly higher for the central channel compared with other channels. No significant correlations were detected between relaxation indices and other EEG frequencies or channels. The causal relationships between relaxation and alpha power at central and frontal channels warrant further study.

neuroscience↗

Decoding time-resolved neural representations of orientation ensemble perception

The visual system is capable of computing summary statistics of multiple visual elements at a glance. While numerous studies have demonstrated ensemble perception across different visual features, the timing at which the visual system forms an ensemble representation remains unclear. This is mainly because most previous studies did not uncover time-resolved neural representations during ensemble perception. Here we used orientation ensemble discrimination tasks along with EEG recordings to decode orientation representations over time while human observers discriminated an average of multiple orientations. We observed alternation in orientation representations over time, with stronger neural representations of the individual elements in a set of orientations, but we did not observe significantly strong representations of the average orientation at any time points. We also found that a cumulative average of the orientation representations over approximately 500 ms converged toward the average orientation. More importantly, this cumulative orientation representation significantly correlated with the individual difference in the perceived average orientation. These findings suggest that the visual system gradually extracts an orientation ensemble, which may be represented as a cumulative average of transient orientation signals, through selective processing of a subset of multiple orientations that occurs over several hundred milliseconds.

neuroscience↗

Immediate effect of quadri-pulse stimulation on human brain microstructures

Several studies have implied that human brain microstructures can change immediately after a behavioral training. However, since widespread regions are involved in behavioral training, it remains unclear whether the microstructure in the living human brain changes immediately after the change in activity of a specific brain area. Hence, we aimed to examine whether the microstructures in the human brain change after the increase and decrease in the specific brain activity by repetitive transcranial magnetic stimulation, namely quadri-pulse stimulation (QPS). Right-handed healthy adults underwent both the excitatory (QPS5) and inhibitory (QPS50) QPS protocols over the left M1. Before and after QPS, diffusion MRI and resting-state fMRI scans were collected to detect any microstructural (fractional anisotropy [FA] and mean diffusivity [MD] values) and functional (functional connectivity between the bilateral M1) changes after QPS5 and QPS50. As a result, we observed no statistically significant change in FA or MD values after either QPS5 or QPS50 in cerebral cortex. This suggests that the brain activity change in widespread area is required to induce microstructural change immediately.

neuroscience↗

Transcranial alternating current stimulation affects several alpha components depending on their frequencies relative to the stimulation frequency

BackgroundThe aftereffects of transcranial alternating current stimulation (tACS), especially targeting occipital alpha oscillations, have been reported to show large individual differences in behavioural effects and neural responsiveness. We predicted that this variance at least partly originates from the fact that multiple alpha components are affected differently by alpha-tACS. ObjectiveTo test the above prediction, we decomposed several alpha components from the data and evaluated the aftereffects separately for each component and participant. More specifically, we tested how the difference between the stimulation frequency and peak frequency influences the aftereffects of tACS on each alpha component. MethodsEighteen participants received 20-min tACS or sham stimulation on separate days. Ten minutes of magnetoencephalography data were collected before and after stimulation, and spectral analysis was performed with a high-frequency resolution (0.1 Hz) to disentangle different alpha components based on the difference in peak frequencies and spatial patterns. Results: The results revealed three alpha components with slightly different frequencies. tACS increased or decreased the power of these alpha components depending on the relative frequency difference from electrical stimulation. Furthermore, observable components differed among participants, possibly because of anatomical differences in each alpha source. ConclusionWhen each alpha component is not analysed separately, the change in overall alpha power will be a combination of decreased or increased components, and inter-individual differences will become larger. Our study highlights the importance of noting the presence of multiple alpha components with relatively small differences in the peak frequency for experimental design and analysis.

neuroscience↗

Attentional rhythmic blink: Theta/Alpha balance in neural oscillations determines the rhythmicity in visual sampling

Brain oscillations in the theta (3-7 Hz) and alpha (7-13 Hz) bands are implicated in visual perception and attention. We show that in an attentional blink paradigm, where the task requires detecting two targets presented in rapid succession, perceptual performance varied with the rhythms at these two frequencies, which we name attentional rhythmic blink. In the absence of distractors, second target detection performance fluctuated at the theta rhythm, but the fluctuation frequency shifted toward alpha rhythm when distractors were interspersed with the targets. We further show, in magnetoencephalography experiments, that a change in the dominant frequency of ongoing neural oscillations accompanied those in perceptual performance, with the parietal theta being more pronounced in the no-distractor and the occipital alpha in the distractor conditions, respectively. We propose that perceptual rhythms may depend on the power balance between ongoing neural oscillations, determined by the task-specific demand.

neuroscience↗

Quadripulse Stimulation: A Replication Study with A Newly Developed Stimulator

Quadripulse stimulation (QPS) is a promising patterned repetitive transcranial magnetic stimulation protocol, which allows the modulation of brain activity for over one hour after the stimulation. Recently, Deymed Diagnostic developed a new stimulator specifically designed to deliver QPS (DuoMAG MP-Quad, https://deymed.com/duomag-qps). The properties of the after-effect with this new stimulator were expected to parallel those obtained with another stimulator, the Magstim stimulator, which is currently used in the psychological and clinical research but not commercially available anymore. Nevertheless, experimental validation of DuoMAG MP-Quad was still warranted. We thus studied the QPS after-effect induced by this stimulator. As a result, motor evoked potentials were found to be bidirectionally modulated by the QPS for more than one hour, consistent with previous studies using the Magstim stimulator. Moreover, the degree of the after-effect was comparable to the after-effect induced by the other stimulator. Taken together, we conclude that the newly developed QPS stimulator is as effective as the Magstim stimulator.

neuroscience↗

Microstructural Properties of Human Brain Revealed by Fractional Anisotropy can Predict the After-effect of Intermittent Theta Burst Stimulation

Intermittent theta burst stimulation (iTBS) delivered by transcranial magnetic stimulation (TMS) produces a long term potentiation (LTP)-like after-effect useful for investigations of cortical function and of potential therapeutic value. However, the iTBS-evoked after-effect over the primary motor cortex (M1) as measured by changes in motor evoked potential (MEP) amplitude exhibits a largely unexplained variability across individuals. Here, we present evidence that individual differences in white and grey matter microstructural properties revealed by fractional anisotropy (FA) predict the magnitude of the iTBS-induced after-effect over M1. The MEP amplitude change in the early phase (5-10 min) post-iTBS was associated with FA values in white matter tracts such as right superior longitudinal fasciculus and corpus callosum. In contrast, the MEP amplitude change in the late phase (15-30 min) post-iTBS was associated with FA in grey matter, primarily in right frontal cortex. These results suggest that the microstructural properties of regions connected directly or indirectly to the target region (M1) are crucial determinants of the iTBS after-effect. FA values indicative of these microstructural differences can predict the potential effectiveness of rTMS for both investigational use and clinical application.

neuroscience↗

Macromolecular tissue volume mapping of lateral geniculate nucleus subdivisions in living human brains

The human lateral geniculate nucleus (LGN) is composed mainly of the magnocellular and parvocellular subdivisions. The non-invasive identification of these subdivisions is, however, difficult due to the small size of the LGN. Here we propose a method to identify these subdivisions by combining two structural MR measures: high-resolution proton-density weighted images and macromolecular tissue volume maps. We collected MRI data from 15 healthy subjects and found that the spatial organization of these subdivisions identified by our method was consistent with post-mortem histological data. Furthermore, the stimulus selectivity in these regions measured by functional MRI was consistent with physiological studies. These results suggest that macromolecular tissue volume mapping is a promising approach to evaluating the tissue properties of LGN subdivisions in living humans. This method potentially will enable neuroscientific and clinical hypotheses about the human LGN to be tested.

neuroscience↗

A colorimetric comparison of sunless with natural skin tan

The main ingredient of sunless tanning products is dihydroxyacetone (DHA). DHA reacts with the protein and amino acid composition in the surface layers of the skin, producing melanoidins, which changes the skin colour, imitating natural skin tan caused by melanin. The purpose of this study was to characterise DHA-induced skin colour changes and to test whether we can predict the outcome of DHA application on skin tone changes. To assess the DHA-induced skin colour shift quantitatively, colorimetric and spectral measurements of the inner forearm were obtained before, four hours and 24 hours after application of a 7.5% concentration DHA gel in the experimental group (n = 100). In a control group (n = 60), the same measurements were obtained on both the inner forearm (infrequently sun-exposed) and the outer forearm (frequently sun-exposed); the difference between these two areas was defined as the naturally occurring tan. Skin colour shifts caused by DHA tanning and by natural tanning were compared in terms of lightness (L*), redness (a*) and yellowness (b*) in the standard CIELAB colour space. Naturalness of the DHA-induced skin tan was evaluated by comparing the trajectory of the chromaticity distribution in (L*, b*) space with that of naturally occurring tan. Twenty-four hours after DHA application, approximately 20% of the skin colour samples became excessively yellow, with chromaticities outside the natural range in (L*, b*) space. A principal component analysis was used to characterise the tanning pathway. Skin colour shifts induced by DHA were predicted by a multiple regression on the chromaticities and the skin properties. The model explained up to 49% of variance in colorimetric components with a median error of less than 2 {Delta}E. We conclude that the control of both the magnitude and the direction of the colour shift is a critical factor to achieve a natural appearance.

neuroscience↗