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Alessi, J. V.

Publications and source records attributed to Alessi, J. V..

2 recordsLinked to original sources

Pan-cancer spatial characterization of key immune biomarkers in the tumor microenvironment

Deciphering the composition and spatial organization of the tumor immune microenvironment (TiME) is key to uncovering the mechanisms driving cancer progression and treatment response. Spatial biology techniques like multiplex immunofluorescence (mIF) offer detailed insights into the TiME but are often limited to retrospective research studies of individual cancer types. Conversely, bulk omics techniques have been studied in pan-cancer settings but fail to capture single-cell spatial information. Here, we provide a pan-cancer spatial characterization of key biomarkers (CD8, FOXP3, PD-1, PD-L1) of the TiME using data from a mIF assay performed prospectively in a clinical setting on 2,019 tumors across 14 major cancer types. By integrating interpretable compositional and spatial metrics, we identified patterns of TiME variation that are conserved across cancer types and stages. We assess associations between these TiME spatial factors and tumor, genomic, and clinical features, where the results both extend prior findings and uncover new links. Altogether, our findings offer pan-cancer insights of the TiME to further the fields of spatial biology and cancer immunology.

cancer biology↗

Craters on the melanoma surface facilitate tumor-immune interactions and demonstrate pathologic response to checkpoint blockade in humans

Immunotherapy leads to cancer eradication despite the tumors immunosuppressive environment. Here, we used extended long-term in-vivo imaging and high-resolution spatial transcriptomics of endogenous melanoma in zebrafish, and multiplex imaging of human melanoma, to identify domains that facilitate immune response during immunotherapy. We identified crater-shaped pockets at the margins of zebrafish and human melanoma, rich with beta-2 microglobulin (B2M) and antigen recognition molecules. The craters harbor the highest density of CD8+ T cells in the tumor. In zebrafish, CD8+ T cells formed prolonged interactions with melanoma cells within craters, characteristic of antigen recognition. Following immunostimulatory treatment, the craters enlarged and became the major site of activated CD8+ T cell accumulation and tumor killing that was B2M dependent. In humans, craters predicted immune response to ICB therapy, showing response better than high T cell infiltration. This marks craters as potential new diagnostic tool for immunotherapy success and targets to enhance ICB response.

cancer biology↗