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Al-Dhayani, K. M.

Publications and source records attributed to Al-Dhayani, K. M..

2 recordsLinked to original sources

Childhood Trauma and Transdiagnostic Mental Health Outcomes Among Adults in 17 Arab Countries: A Multinational Cross-Sectional Study Using a Latent Global Trauma Model

Background: Childhood trauma is a well-established risk factor for adverse mental health outcomes, yet large-scale cross-national evidence from the Arab region remains limited. This study examined the prevalence of childhood trauma and its associations with multiple transdiagnostic outcomes across 17 Arab countries. Methods: A cross-sectional online survey was conducted between September and October 2025 among 6,181 adults from 17 Arab countries. Childhood trauma was assessed using the Childhood Trauma Questionnaire-Short Form (CTQ-SF). Transdiagnostic mental health outcomes included depression, anxiety, posttraumatic stress symptoms (PTSS), maladaptive behavior, and social/functional impairment. Descriptive statistics, Pearson correlations, and multiple linear regression analyses were performed via IBM SPSS Statistics. Confirmatory factor analysis and structural equation modeling were conducted via R (Lavaan) to evaluate a second-order latent construct representing global childhood trauma. Results: Childhood trauma was widely reported across the sample, with physical neglect and emotional neglect emerging as the most frequently endorsed domains. All trauma domains were significantly associated with poorer mental health outcomes (p < .001). In regression analyses adjusted for demographic factors, emotional abuse emerged as the strongest predictor of depression ({beta} = .472, p < .001) and PTSS ({beta} =.439, p < .001). Structural equation modeling supported a second-order global trauma construct, which showed strong associations with depression ({beta} = .70), anxiety ({beta} = .64), PTSS ({beta} = .68), maladaptive behavior ({beta} = .68), and social impairment ({beta} = .67). This latent factor showed strong associations with all mental health outcomes, explaining substantial variance in depression (R2 = .52), anxiety (R2 = .43), and PTSS (R2 = .48). The structural model demonstrated borderline-to-acceptable fit (CFI = .899, TLI = .890, RMSEA = .058, SRMR = .085), supporting the hypothesized latent structure while indicating scope for further model refinement. Conclusions: Childhood trauma is highly prevalent across the Arab region and is strongly associated with multiple dimensions of psychological distress, highlighting the urgent need for trauma-informed prevention, screening, and early intervention programs in the Arab region.

neuroscience↗

Therapeutic Equivalence, Immunogenicity, and Safety of Euvichol Oral Cholera Vaccine Formulations Compared with WHO-prequalified Shanchol vaccine in Healthy Children and Adults: A Systematic Review and Meta-Analysis of Randomised Controlled Trials

Background: Global oral cholera vaccine (OCV) supply shortages and the retirement of Shanchol necessitate absolute reliance on alternative formulations. We conducted a systematic review and meta-analysis to evaluate the immunogenicity and safety of Euvichol variants compared with the historical Shanchol benchmark. Methodology/Principal Findings: A searched PubMed, Embase, MEDLINE, Scopus, and Cochrane CENTRAL up to May 2026 for randomized controlled trials (RCTs) comparing any Euvichol variant against Shanchol in healthy populations aged [&ge;]1 year. Primary outcomes were vibriocidal seroconversion rates at 14 days post-dose 2 pooled as Risk Ratios (RRs) via Mantel-Haenszel fixed-effects models. Five RCTs comprising 7,253 participants were included. Euvichol formulations demonstrated non-inferior, equivalent seroconversion rates compared with Shanchol for both Vibrio cholerae O1 Inaba (RR 1.00, 95% CI 0.98-1.02; I2=0%) and O1 Ogawa (RR 1.01, 95% CI 0.99-1.04; I2=26%). Log-transformed Geometric Mean Titers confirmed clinical equivalence for Inaba (MD 0.02, 95% CI -0.01 to 0.05) and Ogawa (MD 0.00, 95% CI -0.03 to 0.03). Overall safety was balanced between arms, showing no significant variation in the risk of any solicited adverse event (RR 0.91, 95% CI 0.75-1.11) or specific symptoms including fever (RR 0.84, 95% CI 0.52-1.35). Serious adverse events were rare and uniformly unrelated to vaccination. Conclusions/Significance: Euvichol variants demonstrate immunogenic non-inferiority and interchangeable safety thresholds compared with Shanchol. These findings robustly support the large-scale integration of modern Euvichol-Plus and streamlined Euvichol-S formulations to stabilize global OCV stockpiles.

pharmacology and toxicology↗