Biology subjects

Abbas-Zadeh, M.

Publications and source records attributed to Abbas-Zadeh, M..

2 recordsLinked to original sources

bioRxiv2020

Effect of MIND Diet Intervention on Cognitive Performance and Brain Structure in Healthy Obese Women: A Randomized Controlled Trial

Background and AimPrevious studies suggested adherence to recently developed Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) associated with cognitive performance. There was no prior Randomized controlled Trial (RCT) to investigate this association. This study aimed to examine the effect of MIND dietary pattern on features of cognitive performance and also changes in brain structure in healthy obese women. MethodsAs a total of 50 obese women assessed for eligibility, we randomly allocated 40 participants with mean BMI 32 {+/-} 4.31 and mean age 48 {+/-} 5.38 years to either calorie-restricted modified MIND diet or a calorie-restricted standard control diet. Change in cognitive performance was the primary outcome measured with a comprehensive neuropsychological test battery. We also performed voxel-based morphometry as a secondary outcome to quantify the differences in brain structure. All of the measurements administered at baseline and three months follow up. ResultsThirty-seven participants (MIND group=22 and control group=15) completed the study. The results found in the MIND diet group working memory +1.37 (95% CI: 0.79,1.95), verbal recognition memory +4.85 (95% CI: 3.30,6.40), and attention +3.75 (95% CI: 2.43,5.07) improved more compared with the control group (ps < 0.05). Results of brain MRI consists of an increase in surface area of inferior frontal gyrus in the MIND diet group. Furthermore, the results showed a decrease in the cerebellum-white matter and cerebellum-cortex in two groups of study. Still, the effect in the MIND group was greater than the control group. ConclusionsThe study findings declare for the first time that the MIND diet intervention can reverse the destructive effects of obesity on cognition and brain structure, which could be strengthened by a modest calorie restriction.

neuroscience↗

bioRxiv2019

Dual-task Interference in a Simulated Driving Environment: Serial or Parallel Processing?

When humans are required to perform two tasks concurrently, their performances decrease as the two tasks get closer together in time. This effect is known as dual-task interference. This limitation of the human brain could have lethal effects during demanding everyday tasks such as driving. Are the two tasks processed serially or in parallel during dual-task performance in naturalistic settings? Here, we investigated dual-task interference in a simulated driving environment and investigated the serial/parallel nature of processing during dual-task performance. Participants performed a lane change task on a desktop computer, along with an image discrimination task. We systematically varied the time difference between the onset of the two tasks (Stimulus Onset Asynchrony, SOA) and measured its effect on the amount of dual-task interference. Results showed that the reaction times (RTs) of two tasks in the dual-task condition were higher than those in the single-task condition. SOA influenced RTs of both tasks when they were presented second and the RTs of the image task when it was presented first. Manipulating the predictability of the order of the two tasks, we showed that unpredictability attenuated the effect of SOA by changing the order of the response to the two tasks. Next, using drift-diffusion modeling, we modeled the reaction time and choice of the subjects during dual-task performance in both predictable and unpredictable task order conditions. The modeling results indicated that performing two tasks concurrently, affects both the rate of evidence accumulation and the delays outside the evidence accumulation period, suggesting that the two tasks are performed in a partial-parallel manner. These results extend the findings of previous dual-task experiments to more naturalistic settings and deepen our understanding of the mechanisms of dual-task interference.

neuroscience↗